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[突尼斯老年女性乳腺癌。对106例65岁以上患者的回顾性研究]

[Breast cancer in elderly women in Tunisia. Retrospective study of 106 patients older than 65 years].

作者信息

Gharbi Olfa, Landolsi Amel, Nouira Monia, Ben Fatma Leïla, Bibi Mohamed, Korbi Sadok, Bakir Dagla, Kallel Lamia, Khairi Hedi, Beh Ahmed Slim

机构信息

Service de Médecine Carcinologique, CHU.F.HACHED Sousse, Tunisie.

出版信息

Tunis Med. 2003 Sep;81(9):696-701.

Abstract

To report the epidemiological profile, anatomo - clinic, prognostic and therapeutic of breast cancers in aged woman from the region of the Center of Tunisia. Our retrospective study concern 106 patients with mammary cancers treated between January 1990 and December 1997 at the Farhat Hached Hospital in Sousse (Tunisia). The mean age was 71 years (extremes 65-91), 66% of the patients had an age more than 75 years, the mean age at the menopause was of 50 years. The size middle clinic was of 50 mm, 45.3 % of tumors was classed T4, 39.6 % T3. 39.6% of patients have a clinical axillary adenopathis. 14.2% of patients have metastases at diagnostics. 62.5% of the cases have a high histo-pronostic grading. The prognostic factor analysis recovered in multivary survey two parameters significatifs for the survival: the size tumoral (p <0.005) and the presence of metastases at the time of the diagnosis (p <0.001). The biologic and evolutionary features of the cancer of the breast in the aged woman bring to consider the hormonal approach like the most logical, especially for the patients bearers of hormonosensibles tumors, of or the interest of the systematic dosage of the hormonal receptors.

摘要

报告突尼斯中部地区老年女性乳腺癌的流行病学特征、解剖 - 临床特征、预后及治疗情况。我们的回顾性研究涉及1990年1月至1997年12月期间在苏塞(突尼斯)法哈特·哈谢德医院接受治疗的106例乳腺癌患者。平均年龄为71岁(范围65 - 91岁),66%的患者年龄超过75岁,绝经平均年龄为50岁。临床肿瘤大小中位数为50毫米,45.3%的肿瘤分类为T4,39.6%为T3。39.6%的患者有临床腋窝淋巴结肿大。14.2%的患者在诊断时有转移。62.5%的病例组织学预后分级高。在多变量调查中,预后因素分析发现两个对生存有显著意义的参数:肿瘤大小(p <0.005)和诊断时是否存在转移(p <0.001)。老年女性乳腺癌的生物学和演变特征使得激素治疗方法被认为是最合理的,特别是对于激素敏感肿瘤患者,以及激素受体系统检测的意义。

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