Zhu Kathy Q, Carrougher Gretchen J, Gibran Nicole S, Isik F Frank, Engrav Loren H
Department of Surgery, Division of Plastic Surgery, University of Washington, Seattle, Washington 98104, USA.
Wound Repair Regen. 2007 Sep-Oct;15 Suppl 1(Suppl 1):S32-9. doi: 10.1111/j.1524-475X.2007.00223.x.
Hypertrophic scarring after burns is an unsolved problem and remains as devastating today as it was in the 40s and it may be that the main reason for this is the lack of an accepted, useful animal model. The female, red Duroc pig was described as a model of hypertrophic scarring nearly 30 years ago but then vanished from the literature. This seemed strange since the authors reported that 12 of 12 pigs developed thick scar. In the mid 90s we explored the model and found that, indeed, the red Duroc pig does make thick scar. Other authors have established that the Yorkshire pig does not heal in this fashion so there is the possibility of a same species control. We have continued to explore the Duroc/Yorkshire model and herein describe our experiences. Is it a perfect model of hypertrophic scarring? No. Is it a useful model of hypertrophic scarring? Time will tell. We have now obtained gene expression data from the Duroc/Yorkshire model and analysis is underway.
烧伤后的增生性瘢痕是一个尚未解决的问题,如今它依然具有极大的破坏性,就如同40年代一样,造成这种情况的主要原因可能是缺乏一个被广泛认可且实用的动物模型。近30年前,雌性红色杜洛克猪被描述为增生性瘢痕的模型,但随后却从文献中消失了。这似乎很奇怪,因为作者报告称12头猪中有12头都形成了厚瘢痕。在90年代中期,我们对该模型进行了探索,发现红色杜洛克猪确实会形成厚瘢痕。其他作者已经证实约克夏猪不会以这种方式愈合,所以存在同物种对照的可能性。我们继续探索杜洛克/约克夏模型,并在此描述我们的经验。它是增生性瘢痕的完美模型吗?不是。它是增生性瘢痕的有用模型吗?时间会给出答案。我们现在已经从杜洛克/约克夏模型中获得了基因表达数据,分析正在进行中。