Handschel Jörg, Brüssermann Sabine, Depprich Rita, Ommerborn Michelle, Naujoks Christian, Kübler Norbert R, Meyer Ulrich
Klinik für Kiefer- und Plastische Gesichtschirurgie, Heinrich-Heine-Universität, Moorenstr. 5, 40225, Düsseldorf, Germany.
Mund Kiefer Gesichtschir. 2007 Nov;11(5):285-90. doi: 10.1007/s10006-007-0073-5. Epub 2007 Sep 4.
Chronic osteomyelitis of the jaw is a relapsing disease with multiple treatment strategies described in the literature. Hyperbaric oxygen therapy is one of them. The purpose of this study was to evaluate the clinical outcome of hyperbaric oxygen therapy in these patients.
All patients with a chronic osteomyelitis of the mandible who received in our department hyperbaric oxygen therapy between 2000 and 2004 were included in this study. The clinical outcome (lack of symptoms e.g. pain, swelling, etc.) was the pivotal evaluation parameter. All patients were divided in three groups according to their medical history. Group 1: All patients with osteomyelitis of the mandible, who received no treatment before. Group 2: All patients with one local relapse, who received only antimicrobial treatment. Group 3: Patients with at least one local relapse after antimicrobial and surgical treatment.
27 patients were evaluated in this study. Seven out of 13 patients in group 1 were relapse free after performing 40 hyperbaric oxygen therapies. However, only 4 of 9 patients in group 3 were relapse free after treatment. In group 2 the hyperbaric oxygen therapy was successful particularly in the younger patients (3 of 4).
Adjuvant hyperbaric oxygen therapy was successful in the treatment of patients with chronic recurrent osteomyelitis of the mandible. Therefore, it is an treatment option which can avoid ablative surgery in some cases.
颌骨慢性骨髓炎是一种复发性疾病,文献中描述了多种治疗策略。高压氧治疗是其中之一。本研究的目的是评估高压氧治疗这些患者的临床疗效。
本研究纳入了2000年至2004年期间在我科接受高压氧治疗的所有下颌骨慢性骨髓炎患者。临床疗效(无疼痛、肿胀等症状)是关键评估参数。所有患者根据病史分为三组。第1组:所有之前未接受过治疗的下颌骨骨髓炎患者。第2组:所有有一次局部复发且仅接受过抗菌治疗的患者。第3组:抗菌和手术治疗后至少有一次局部复发的患者。
本研究共评估了27例患者。第1组13例患者中有7例在接受40次高压氧治疗后未复发。然而,第3组9例患者中只有4例治疗后未复发。在第2组中,高压氧治疗对年轻患者尤其成功(4例中有3例)。
辅助高压氧治疗成功地治疗了下颌骨慢性复发性骨髓炎患者。因此,在某些情况下,它是一种可以避免切除手术的治疗选择。