糖皮质激素诱导肿瘤坏死因子受体（GITR）及其配体对肺部急慢性炎症的调节作用

Modulation of acute and chronic inflammation of the lung by GITR and its ligand.

作者信息

Nocentini Giuseppe, Cuzzocrea Salvatore, Bianchini Rodolfo, Mazzon Emanuela, Riccardi Carlo

机构信息

Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Via del Giochetto, 06100 Perugia, Italy.

出版信息

Ann N Y Acad Sci. 2007 Jun;1107:380-91. doi: 10.1196/annals.1381.040.

DOI:10.1196/annals.1381.040

PMID:17804566

Abstract

Glucocorticoid-induced TNFR-related (GITR) protein, a member of the tumor necrosis factor receptor superfamily, is expressed in many components of the innate and adaptive immune system and modulates their activation following interaction with its ligand (GITRL). Here we review and discuss results described in previous publications where the role of the GITR/GITRL system in lung inflammation was evaluated using two experimental systems. We also discuss the proinflammatory role played by the GITR/GITRL system and the potential use of GITR fusion protein in inhibiting inflammation.

摘要

糖皮质激素诱导的肿瘤坏死因子受体相关（GITR）蛋白是肿瘤坏死因子受体超家族的成员，在天然免疫和适应性免疫系统的许多成分中表达，并在与配体（GITRL）相互作用后调节其激活。在此，我们回顾并讨论先前出版物中描述的结果，其中使用两个实验系统评估了GITR/GITRL系统在肺部炎症中的作用。我们还讨论了GITR/GITRL系统发挥的促炎作用以及GITR融合蛋白在抑制炎症方面的潜在用途。