Science. 1977 Jul 8;197(4299):179-80. doi: 10.1126/science.197.4299.179.
The intracarotid injection of both synthetic melanocyte-stimulating hormone release-inhibiting factor (MIF) and purified MIF prepared from bovine hypothalami induces arginine vasotocin release into cerebrospinal fluid of cats and significantly decreases the pineal arginine vasotocin content at 5 minutes after the injection. The present results demonstrate an extrapituitary endocrine effect of synthetic and purified bovine MIF.
静脉内注射合成的促黑激素释放抑制因子(MIF)和从牛下丘脑提取的纯化 MIF 都会引起猫的血管加压素释放到脑脊液中,并在注射后 5 分钟显著降低松果体血管加压素的含量。这些结果证明了合成的和纯化的牛 MIF 具有垂体外内分泌效应。