血清抗子宫内膜抗体与子宫内膜异位症的诊断
Serum antiendometrial antibodies and diagnosis of endometriosis.
作者信息
Randall Gary W, Gantt Pickens A, Poe-Zeigler Robin L, Bergmann Cynthia A, Noel Marshall E, Strawbridge Wendy R, Richardson-Cox Barbara, Hereford John R, Reiff Robert H
机构信息
Department of Obstetrics and Gynecology, WVU School of Medicine, Charleston Division, Charleston, WV 23502, USA.
出版信息
Am J Reprod Immunol. 2007 Oct;58(4):374-82. doi: 10.1111/j.1600-0897.2007.00523.x.
PROBLEM
The purpose of the present prospective multi-center study is to investigate the relationship between laparoscopic diagnosis of endometriosis and results of a serum antiendometrial antibody (AEA) assay.
METHOD OF STUDY
Indirect immunofluorescence detection of AEA was performed on serum specimens from patients presenting with dysmenorrhea or chronic pelvic pain and infertility (n = 2609) utilizing frozen sections of endometrium acquired on cycle days 18-21 from normally cycling women without endometriosis. Diagnostic laparoscopy was performed within 1 year of AEA assay on 527 tested women.
RESULTS
The relationship between the serum AEA and laparoscopic verification was characterized by a positive predictive value = 88%, negative predictive value = 86%, sensitivity = 87% and specificity = 87%.
CONCLUSION
The AEA assay is a very good screening test for patients suspected of having endometriosis and should be utilized prior to laparoscopy in diagnostic categories of dysmenorrhea or chronic pelvic pain and infertility.
问题
本前瞻性多中心研究的目的是调查子宫内膜异位症的腹腔镜诊断与血清抗子宫内膜抗体（AEA）检测结果之间的关系。
研究方法
对出现痛经、慢性盆腔疼痛和不孕的患者（n = 2609）的血清标本进行AEA的间接免疫荧光检测，使用从无子宫内膜异位症的正常月经周期女性在月经周期第18 - 21天获取的子宫内膜冷冻切片。在527名接受检测的女性中，在进行AEA检测后的1年内进行了诊断性腹腔镜检查。
结果
血清AEA与腹腔镜检查结果之间的关系表现为：阳性预测值 = 88%，阴性预测值 = 86%，敏感性 = 87%，特异性 = 87%。
结论
AEA检测对于疑似患有子宫内膜异位症的患者是一种非常好的筛查试验，在痛经或慢性盆腔疼痛及不孕的诊断类别中，应在腹腔镜检查之前使用。
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