Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC).
作者信息
Arthurs Claire L, Raftery James, Whitby Helen L, Whitehead Roger C, Wind Natasha S, Stratford Ian J
机构信息
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
出版信息
Bioorg Med Chem Lett. 2007 Nov 1;17(21):5974-7. doi: 10.1016/j.bmcl.2007.07.070. Epub 2007 Aug 21.
PMID:17870533
Abstract
The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented.
摘要
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