Fassett Daniel R, Harrop James S, Maltenfort Mitchell, Jeyamohan Shiveindra B, Ratliff John D, Anderson D Greg, Hilibrand Alan S, Albert Todd J, Vaccaro Alexander R, Sharan Ashwini D
Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
J Neurosurg Spine. 2007 Sep;7(3):277-81. doi: 10.3171/SPI-07/09/277.
The authors undertook this study to evaluate the incidence of spinal cord injury (SCI) in geriatric patients (> or = 70 years of age) and examine the impact of patient age, extent of neurological injury, and spinal level of injury on the mortality rate associated with traumatic SCI.
A prospectively maintained SCI database (3481 patients) at a single institution was retrospectively studied for the period from 1978 through 2005. Parameters analyzed included patient age, admission American Spinal Injury Association (ASIA) motor score, level of SCI, mechanism of injury, and mortality data. The data pertaining to the 412 patients 70 years of age and older were compared with those pertaining to the younger cohort using a chi-square analysis.
Since 1980, the number of SCI-related hospital admissions per year have increased fivefold in geriatric patients and the percentage of geriatric patients within the SCI population has increased from 4.2 to 15.4%. In comparison with younger patients, geriatric patients were found to be less likely to have severe neurological deficits (greater percentage of ASIA Grades C and D injuries), but the mortality rates were higher in the older age group both for the period of hospitalization (27.7% compared with 3.2%, p < 0.001) and during 1-year follow-up. The mortality rates in this older population directly correlate with the severity of neurological injury (1-year mortality rate, ASIA Grade A 66%, Grade D 23%, p < 0.001). The mortality rate in elderly patients with SCI has not changed significantly over the last two decades, and the 1-year mortality rate was greater than 40% in all periods analyzed.
Spinal cord injuries in older patients are becoming more prevalent. The mortality rate in this patient group is much greater than in younger patients and should be taken into account when aggressive interventions are considered and in counseling families regarding prognosis.
作者开展本研究以评估老年患者(≥70岁)脊髓损伤(SCI)的发生率,并探讨患者年龄、神经损伤程度及损伤脊髓节段对创伤性SCI相关死亡率的影响。
对某单一机构前瞻性维护的SCI数据库(3481例患者)进行回顾性研究,研究时间段为1978年至2005年。分析的参数包括患者年龄、入院时美国脊髓损伤协会(ASIA)运动评分、SCI节段、损伤机制及死亡率数据。采用卡方分析将412例70岁及以上患者的数据与年轻队列的数据进行比较。
自1980年以来,老年患者每年因SCI入院的人数增加了五倍,SCI患者群体中老年患者的比例从4.2%增至15.4%。与年轻患者相比,老年患者出现严重神经功能缺损的可能性较小(ASIA C级和D级损伤的比例更高),但在住院期间(27.7%对比3.2%,p<0.001)及1年随访期间,老年组的死亡率更高。该老年人群的死亡率与神经损伤严重程度直接相关(1年死亡率,ASIA A级为66%,D级为23%,p<0.001)。过去二十年中,老年SCI患者的死亡率无显著变化,在所有分析时间段内1年死亡率均超过40%。
老年患者的脊髓损伤正变得越来越普遍。该患者群体的死亡率远高于年轻患者,在考虑积极干预措施及向家属提供预后咨询时应予以考虑。