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带有香芹酮残基的脲和酰胺的合成及其生理活性

Synthesis and physiological activity of ureas and amides with carvone residues.

作者信息

Tachibana Shinya, Maegawa Yoshihumi, Nomura Masato

机构信息

Konan Chemical Industry Co., Ltd., Takatsuki, Osaka, Japan.

出版信息

J Oleo Sci. 2007;56(6):303-7. doi: 10.5650/jos.56.303.

Abstract

The synthesis and herbicidal activity of ureas and amides with carvone residues were examined. (S)-(+)-(1) and (R)-(-)-Carvone(2) were converted to the respectively, primary amines(3) and (4) by oximation and reduction with LiAlH(4). Primary amine derivatives were further converted into the urea and amide compounds (3a) approximately (3e) and (4a) approximately (4e). The herbicidal activity of products (3a) approximately (3e) and (4a) approximately (4e) towards weeds found in a paddy field and field was measured in the pot. Products (3a) showed a particularly strong inhibitory effect on the growth of Amaranthus retroflexus(AR) and Setaria viridis(SV).

摘要

对带有香芹酮残基的脲类和酰胺类化合物的合成及其除草活性进行了研究。(S)-(+)-(1)和(R)-(-)-香芹酮(2)分别通过肟化反应并用LiAlH(4)还原,转化为伯胺(3)和(4)。伯胺衍生物进一步转化为脲类和酰胺类化合物(3a)至(3e)以及(4a)至(4e)。在盆栽试验中测定了产物(3a)至(3e)和(4a)至(4e)对稻田和农田中杂草的除草活性。产物(3a)对反枝苋(AR)和狗尾草(SV)的生长表现出特别强的抑制作用。

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