猫鳞状细胞癌的九天加速放疗方案。
A nine-day accelerated radiation protocol for feline squamous cell carcinoma.
作者信息
Fidel Janean L, Sellon Rance K, Houston Robert K, Wheeler Betsy A
机构信息
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164-6610, USA.
出版信息
Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):482-5. doi: 10.1111/j.1740-8261.2007.00283.x.
Nine cats with oral squamous cell carcinoma were treated with an accelerated radiation protocol (14 fractions of 3.5 Gy in 9 days). Radiation was administered twice daily with a 6hour break between treatments. Median overall survival was 86 +/- 110 days. Median survival for cats with a partial response (n=6) was 60 +/- 7 days, while median survival for cats with a complete response (n=3) was 298 +/- 187 days (P = 0.0639). The accelerated protocol was well tolerated and toxicity in the early and late period was manageable in all cats. Further modification of the protocol is warranted to extend survival.
九只患有口腔鳞状细胞癌的猫接受了加速放疗方案（9天内分14次，每次3.5 Gy）。放疗每天进行两次，两次治疗之间间隔6小时。中位总生存期为86±110天。部分缓解的猫（n = 6）的中位生存期为60±7天，而完全缓解的猫（n = 3）的中位生存期为298±187天（P = 0.0639）。加速方案耐受性良好，所有猫的早期和晚期毒性均可控制。有必要对该方案进行进一步修改以延长生存期。
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