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澳大利亚老年人群中年龄相关性白内障及白内障手术的十年发病率。蓝山眼研究。

Ten-year incidence of age-related cataract and cataract surgery in an older Australian population. The Blue Mountains Eye Study.

作者信息

Kanthan Gowri L, Wang Jie Jin, Rochtchina Elena, Tan Ava Grace, Lee Anne, Chia Ee-Mun, Mitchell Paul

机构信息

University of Sydney Department of Ophthalmology, Center for Vision Research, Westmead Millennium Institute, Westmead Hospital, Sydney, Australia.

出版信息

Ophthalmology. 2008 May;115(5):808-814.e1. doi: 10.1016/j.ophtha.2007.07.008. Epub 2007 Sep 27.

Abstract

PURPOSE

To estimate the 10-year incidence of cataract and cataract surgery in an older Australian population.

DESIGN

Prospective population-based study.

PARTICIPANTS

Persons at least 49 years old living in 2 postcode areas west of Sydney, Australia.

METHODS

Eye examinations were performed at baseline and at 5- and 10-year follow-up visits. Lens photographs were taken and graded by masked graders using the Wisconsin Cataract Grading System.

MAIN OUTCOME MEASURES

Incidences of nuclear cataract, cortical cataract, posterior subcapsular cataract (PSC), and cataract surgery.

RESULTS

Ten-year person-specific incidences were 36.0% for nuclear cataract, 28.0% for cortical cataract, 9.1% for PSC, and 17.8% for cataract surgery. Corresponding rates were 31.7%, 24.4%, 8.2%, and 14.4%, respectively, in men and 39.3%, 30.8%, 9.8%, and 20.1%, respectively, in women. The incidence for each type of cataract and cataract surgery was positively associated with age (P<0.0001). Women had a significantly higher incidence than men for nuclear cataract (P = 0.04), cortical cataract (P = 0.007), any cataract (P = 0.0006), and cataract surgery (P = 0.03) after adjusting for age. There was no significant gender difference for PSC. The mean age at cataract surgery was 75.8 years, and there was no significant gender difference (P = 0.9). Among persons who developed any cataract, 22% had more than one type and 1.3% had all 3 types present. Nuclear cataract and PSC were significantly associated with visual impairment (visual acuity worse than 20/40).

CONCLUSION

Age- and gender-specific cataract incidences in this study were similar to those reported from the U.S. Beaver Dam Eye Study. In this study, 72% of the participants were affected by cataract or had had cataract surgery over the 10-year follow-up period.

摘要

目的

评估澳大利亚老年人群中白内障及白内障手术的10年发病率。

设计

基于人群的前瞻性研究。

参与者

居住在澳大利亚悉尼以西两个邮政编码地区、年龄至少49岁的人群。

方法

在基线以及5年和10年随访时进行眼部检查。拍摄晶状体照片,并由遮蔽分级人员使用威斯康星白内障分级系统进行分级。

主要观察指标

核性白内障、皮质性白内障、后囊下白内障(PSC)及白内障手术的发病率。

结果

核性白内障的10年个体发病率为36.0%,皮质性白内障为28.0%,PSC为9.1%,白内障手术为17.8%。男性相应的发病率分别为31.7%、24.4%、8.2%和14.4%,女性分别为39.3%、30.8%、9.8%和20.1%。每种类型白内障及白内障手术的发病率均与年龄呈正相关(P<0.0001)。调整年龄后,女性核性白内障(P = 0.04)、皮质性白内障(P = 0.007)、任何类型白内障(P = 0.0006)及白内障手术(P = 0.03)的发病率均显著高于男性。PSC在性别上无显著差异。白内障手术的平均年龄为75.8岁,在性别上无显著差异(P = 0.9)。在发生任何类型白内障的人群中,22%患有不止一种类型,1.3%同时患有所有三种类型。核性白内障和PSC与视力损害(视力低于20/40)显著相关。

结论

本研究中特定年龄和性别的白内障发病率与美国比弗迪姆眼研究报告的相似。在本研究中,72%的参与者在10年随访期间受到白内障影响或接受了白内障手术。

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