简单铜盐催化含氮杂环与芳基卤化物和杂芳基卤化物的N-芳基化反应。
Simple copper salt-catalyzed N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides.
作者信息
Zhu Liangbo, Guo Peng, Li Gaocan, Lan Jingbo, Xie Rugang, You Jingsong
机构信息
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Hospital, Sichuan University, Chengdu 610064, PR China.
出版信息
J Org Chem. 2007 Oct 26;72(22):8535-8. doi: 10.1021/jo0712289. Epub 2007 Sep 29.
Relatively mild and highly efficient CuI-catalyzed N-arylation procedures for nitrogen-containing heterocycles (e.g., imidazoles, benzimidazoles, pyrroles, pyrazoles, indoles, triazoles, etc.) with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free primary amine on the aryl halide.
已经开发出相对温和且高效的由碘化亚铜催化的含氮杂环（如咪唑、苯并咪唑、吡咯、吡唑、吲哚、三唑等）与芳基卤化物和杂芳基卤化物的N-芳基化方法。这些方法操作简便，并且能兼容芳基卤化物上的多种官能团，如酯基、腈基、硝基、酮基、游离羟基和游离伯胺基。
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