维甲酸受体

Retinoid receptors.

作者信息

Davidovici Batya B, Tüzün Yalçin, Wolf Ronni

机构信息

The Dermatology Unit, Kaplan Medical Center, 76100 Rechovot, Israel.

出版信息

Dermatol Clin. 2007 Oct;25(4):525-30, viii. doi: 10.1016/j.det.2007.06.016.

DOI:10.1016/j.det.2007.06.016

PMID:17903611

Abstract

"Retinoid" refers to the naturally occurring compounds with vitamin A activity and to synthetic analogues of retinol. Retinoids are key regulators of differentiation, proliferation, and inflammation. Their successful use in the treatment of various skin diseases and neoplasias has revolutionized the practice of dermatology as well as oncology. This article focuses on the retinoid receptors to elucidate our understanding of their complex biologic activity that is reflected in their therapeutic clinical effects as well as in their adverse reactions.

摘要

“类视黄醇”指具有维生素A活性的天然存在的化合物以及视黄醇的合成类似物。类视黄醇是分化、增殖和炎症的关键调节因子。它们在治疗各种皮肤病和肿瘤方面的成功应用彻底改变了皮肤病学和肿瘤学的实践。本文重点关注类视黄醇受体，以阐明我们对其复杂生物学活性的理解，这种活性体现在它们的治疗临床效果以及不良反应中。