Reeves Roger H, Garner Craig C
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Ment Retard Dev Disabil Res Rev. 2007;13(3):215-20. doi: 10.1002/mrdd.20165.
The years 2006 and 2007 saw the publication of three new and different approaches to prevention or amelioration of Down syndrome effects on the brain and cognition. We describe the animal model systems that were critical to this progress, review these independent breakthrough studies, and discuss the implications for therapeutic approaches suggested by each.
2006年和2007年,出现了三种预防或改善唐氏综合征对大脑和认知影响的全新且不同的方法。我们描述了对这一进展至关重要的动物模型系统,回顾了这些独立的突破性研究,并讨论了每项研究对治疗方法的启示。