Chan Dominic C W, Fong Daniel H F, Leung June Y Y, Patil N G, Leung Gilberto K K
Centre for Education and Training, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.
Hong Kong Med J. 2007 Oct;13(5):382-6.
To review the current evidence on the mechanism of actions and clinical applications of maggot debridement therapy.
Literature search of PubMed and Medline was performed up to January 2007.
Original and major review articles related to maggot debridement therapy were reviewed. Key words used in the literature search were 'maggot debridement therapy', 'wound healing', and 'chronic wound management'.
All relevant English and Chinese articles.
The mechanism of such maggot therapy was shown to be due to the debridement, disinfection, and wound healing enhancement actions of maggot excretions/secretions. The efficacy of maggot debridement therapy in chronic wound management has been demonstrated in chronic venous ulcers, pressure ulcers, and diabetic ulcers. There is also a new delivery system for the excretions/secretions, which has been shown to be as effective as using live maggots.
Maggot debridement therapy has been shown to be a safe and effective means of chronic wound management. However, there are a number of limitations when considering its local applicability. Future development of the delivery system may help to overcome some of these limitations and improve its acceptability.
综述蛆虫清创疗法作用机制及临床应用的现有证据。
检索截至2007年1月的PubMed和Medline文献。
对与蛆虫清创疗法相关的原始及主要综述文章进行综述。文献检索使用的关键词为“蛆虫清创疗法”、“伤口愈合”和“慢性伤口处理”。
所有相关的英文和中文文章。
蛆虫疗法的作用机制表明是由于蛆虫排泄物/分泌物的清创、消毒及促进伤口愈合作用。蛆虫清创疗法在慢性伤口处理中的疗效已在慢性静脉溃疡、压疮和糖尿病溃疡中得到证实。此外，还有一种新的排泄物/分泌物递送系统，已证明其与使用活蛆虫一样有效。
蛆虫清创疗法已被证明是慢性伤口处理的一种安全有效的方法。然而，在考虑其局部适用性时存在一些局限性。递送系统的未来发展可能有助于克服其中一些局限性并提高其可接受性。
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