用于研究人FPRL1（或ALXR）受体在炎症中作用的新型“化学探针”。
New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.
作者信息
Frohn Mike, Xu Han, Zou Xiaoming, Chang Catherine, McElvaine Michele, Plant Matthew H, Wong Min, Tagari Philip, Hungate Randall, Bürli Roland W
机构信息
Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
出版信息
Bioorg Med Chem Lett. 2007 Dec 1;17(23):6633-7. doi: 10.1016/j.bmcl.2007.09.043. Epub 2007 Sep 15.
PMID:17920884
Abstract
We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.
摘要
我们报道了新型N-取代苯并咪唑11作为一种强效且选择性的人甲酰肽受体样1（hFPRL1）激动剂的研发情况。该化合物及其活性较低的对映体12被确定为用于体外研究受体功能的有用工具。
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