奥氮平所致抗精神病药恶性综合征的非典型表现

Atypicality in presentation of neuroleptic malignant syndrome caused by olanzapine.

作者信息

Mishra Biswaranjan, Mishra Baikunthanath, Sahoo Saddichha, Arora Manu, Khess C R J

机构信息

Dept. of Psychiatry, Central Institute of Psychiatry, Ranchi, India.

出版信息

Indian J Med Sci. 2007 Oct;61(10):570-3.

PMID:17932448

Abstract

Neuroleptic malignant syndrome (NMS) is the most serious of acute neurological side effects produced by antipsychotic medication, characterized by hyperthermia, rigidity, altered consciousness and autonomic dysfunction, the prevalence of which varies from 0.4-1.4%. NMS is usually seen in treatment with high potency typical antipsychotics and very rarely with atypical antipsychotics. However, NMS cases have been reported with risperidone, clozapine, olanzapine and quetiapine. The presentations of NMS have often varied and we report another atypicality in presentation of NMS due to olanzapine use.

摘要

抗精神病药物所致的神经阻滞剂恶性综合征（NMS）是最严重的急性神经副作用，其特征为高热、强直、意识改变及自主神经功能障碍，患病率为0.4%-1.4%。NMS通常见于使用高效能传统抗精神病药物治疗时，很少见于使用非典型抗精神病药物时。然而，已有使用利培酮、氯氮平、奥氮平和喹硫平后发生NMS的病例报告。NMS的表现常常各异,我们报告1例因使用奥氮平导致的NMS的不典型表现。