Mimura T, Mimura Y, Arimoto A, Amano S, Yamagami S, Funatsu H, Usui T, Noma H, Honda N, Okamoto S
Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Eye (Lond). 2009 Jan;23(1):63-6. doi: 10.1038/sj.eye.6702999. Epub 2007 Oct 12.
External allergens are the main causative factor in the pathogenesis of allergic diseases; however, little is known about internal factors such as the biometrical structure of the eye. We investigated the relationship between refractive error and allergic conjunctivitis in order to reveal possible insights into the pathogenesis in 1015 subjects.
The patients were divided into four groups: contact lens wearers with allergic conjunctivitis (n=73), contact lens wearers without allergic conjunctivitis (n=59), non-contact lens wearers with allergic conjunctivitis (n=224), and non-contact lens wearers without allergic conjunctivitis (n=659). The spherical power, cylindrical power, corneal radius, and minimum and maximum corneal refractive powers were measured in all subjects.
In the non-contact lens wearers, the spherical equivalent and spherical power were significantly lower in patients with allergic conjunctivitis than in patients without allergic conjunctivitis (-3.01+/-3.83 D vs-1.36+/-3.08 D, P<0.0001, and -2.64+/-3.63 D vs-1.05+/-2.88 D, P<0.0001, respectively), while there was no significant difference in any of the parameters between the contact lens wearers with and without allergic conjunctivitis.
Refractive error may be a risk factor for allergic conjunctivitis.
外部过敏原是过敏性疾病发病机制中的主要致病因素；然而，对于诸如眼睛生物测量结构等内部因素知之甚少。我们对1015名受试者进行了研究，以揭示屈光不正与过敏性结膜炎之间的关系，从而深入了解其发病机制。
将患者分为四组：患有过敏性结膜炎的隐形眼镜佩戴者（n = 73）、未患过敏性结膜炎的隐形眼镜佩戴者（n = 59）、患有过敏性结膜炎的非隐形眼镜佩戴者（n = 224）以及未患过敏性结膜炎的非隐形眼镜佩戴者（n = 659）。测量了所有受试者的球镜度数、柱镜度数、角膜半径以及角膜最小和最大屈光力。
在非隐形眼镜佩戴者中，患有过敏性结膜炎的患者的等效球镜度数和球镜度数显著低于未患过敏性结膜炎的患者（分别为-3.01±3.83 D对-1.36±3.08 D，P<0.0001；以及-2.64±3.63 D对-1.05±2.88 D，P<0.0001），而在患有和未患过敏性结膜炎的隐形眼镜佩戴者之间，任何参数均无显著差异。
屈光不正可能是过敏性结膜炎的一个危险因素。
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