甘蔗废蜜中的酚类化合物对致龋菌具有抗菌活性。
Phenolic compounds from sugarcane molasses possessing antibacterial activity against cariogenic bacteria.
作者信息
Takara Kensaku, Ushijima Kenji, Wada Koji, Iwasaki Hironori, Yamashita Masatsugu
机构信息
Faculty of Agriculture, University of the Ryukyus, Nishihara-cho, Okinawa, Japan.
出版信息
J Oleo Sci. 2007;56(11):611-4. doi: 10.5650/jos.56.611.
During the course of our research into the use of cane by-products from sugar manufacturing, we have studied the isolation and structural determination of bioactive compounds present in sugarcane molasses. In this study, dehydrodiconiferylalcohol-9'-O-beta-D-glucopyranoside (1) and isoorientin-7, 3'-O-dimethyl ether (2) were isolated as antibacterial active compounds against cariogenic bacteria. Their structures were elucidated by (1)H-NMR, (13)C-NMR and ESI-MS. The activities of these isolated compounds against Streptococcus mutans and Streptococcus sobrinus were assessed by a minimum inhibitory concentration (MIC) test. The MICs of compounds 1 and 2 against both S. mutans and S. sobrinus were >4 mg/mL and 4 mg/mL, respectively.
在我们对制糖过程中甘蔗副产品利用的研究过程中，我们研究了甘蔗 molasses 中存在的生物活性化合物的分离和结构测定。在本研究中，脱氢二松柏醇 -9'-O-β-D-吡喃葡萄糖苷（1）和异荭草素 -7, 3'-O-二甲醚（2）被分离为对致龋菌有抗菌活性的化合物。它们的结构通过（1）H-NMR、（13）C-NMR 和 ESI-MS 进行了阐明。通过最低抑菌浓度（MIC）试验评估了这些分离化合物对变形链球菌和远缘链球菌的活性。化合物 1 和 2 对变形链球菌和远缘链球菌的 MIC 分别 >4 mg/mL 和 4 mg/mL。
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