Mazzone Amelia, Farrugia Gianrico
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Gastroenterol Clin North Am. 2007 Sep;36(3):499-513, vii. doi: 10.1016/j.gtc.2007.07.003.
The enteric nervous system is an independent nervous system with a complexity comparable with the central nervous system. This complex system is integrated into several other complex systems, such as interstitial cells of Cajal networks and immune cells. The result of these interactions is effective coordination of motility, secretion, and blood flow in the gastrointestinal tract. Loss of subsets of enteric nerves, of interstitial cells of Cajal, malfunction of smooth muscle, and alteration in immune cells have been identified as the basis of many motility disorders. The initial factors triggering these changes and how to intervene to prevent, halt, and reverse them needs to be understood.
肠神经系统是一个独立的神经系统，其复杂性与中枢神经系统相当。这个复杂的系统与其他几个复杂系统相互整合，如 Cajal 间质细胞网络和免疫细胞。这些相互作用的结果是有效协调胃肠道的运动、分泌和血流。肠神经亚群的丧失、Cajal 间质细胞的丧失、平滑肌功能障碍以及免疫细胞的改变已被确定为许多运动障碍的基础。需要了解引发这些变化的初始因素以及如何进行干预以预防、阻止和逆转这些变化。
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