莲柏液对放射性皮肤损伤的防治作用

Clinical effects of lianbai liquid in prevention and treatment of dermal injury caused by radiotherapy.

作者信息

Ma Hongbing, Zhang Xiaozhi, Bai Minghua, Wang Xijing

机构信息

Radiotherapy Center of Oncology Department of the Second Hospital Affiliated to Xi'an Jiaotong University, Xi'an 710004, China.

出版信息

J Tradit Chin Med. 2007 Sep;27(3):193-6.

PMID:17955656

Abstract

OBJECTIVE

To observe the effect of Lianbai liquid in prevention and treatment of acute radiation dermal injury.

METHOD

From May 2000 to December 2005, 126 cancer patients were randomly divided into a prevention group of 75 cases given externally topical application of Lianbai liquid since the first radiotherapy, and a control group I of 51 cases given only advice after radiotherapy; while the other 92 cancer patients who had already had grade III acute radiation-induced dermal injury were randomly divided into a treatment group of 54 cases treated by externally topical use of Lianbai liquid, and a control group II of 38 cases treated by topical use of norfloxacin. Clinical evaluation was carried out according to the CTC.V2.0 standard stipulated by NCI for classifying acute radiation dermal injury.

RESULTS

The incidence of skin reaction was 32.0% in the prevention group and 92.2% in the control group I, with an obvious difference between the two groups (chi2=54.163, P<0.01). Mild radioactive reaction (grade I and II) was 28.0% (21/75) in the prevention group and 70.6% (36/51) in the control group I, with a remarkable difference between the two groups (chi2=22.226, P<0.01). The effective rate for grade III dermal injury was 92.6% (50/54) in the treatment group and 65.9% (25/38) in the control group II, with a remarkable difference between the two groups (chi2=6.018, P=0.024). The wound-healing time was 11.07+/-2.21 days in the treatment group and 18.08+/-1.76 days in the control group II, with a remarkable difference between the two groups (u=16.932, P<0.01).

CONCLUSION

Lianbai liquid can effectively prevent the radiation dermatitis, and treat grade III acute radiation dermal injury with obvious curative effect.

摘要

目的

观察连柏液防治急性放射性皮肤损伤的效果。

方法

2000年5月至2005年12月，将126例癌症患者随机分为预防组75例，从首次放疗开始即外用连柏液；对照组I 51例，放疗后仅给予建议。另外92例已发生III级急性放射性皮肤损伤的癌症患者随机分为治疗组54例，外用连柏液治疗；对照组II 38例，外用诺氟沙星治疗。根据美国国立癌症研究所（NCI）规定的CTC.V2.0标准对急性放射性皮肤损伤进行临床评价。

结果

预防组皮肤反应发生率为32.0%，对照组I为92.2%，两组差异明显（χ2=54.163，P<0.01）。预防组轻度放射性反应（I级和II级）为28.0%（21/75），对照组I为70.6%（36/51），两组差异显著（χ2=22.226，P<0.01）。治疗组III级皮肤损伤有效率为92.6%（50/54），对照组II为65.9%（25/38），两组差异显著（χ2=6.018，P=0.024）。治疗组伤口愈合时间为（11.07±2.21）天，对照组II为（18.08±1.76）天，两组差异显著（u=16.932，P<0.01）。