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医学中的纳米粒子:治疗应用与进展。

Nanoparticles in medicine: therapeutic applications and developments.

作者信息

Zhang L, Gu F X, Chan J M, Wang A Z, Langer R S, Farokhzad O C

机构信息

Department of Chemical Engineering and Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

出版信息

Clin Pharmacol Ther. 2008 May;83(5):761-9. doi: 10.1038/sj.clpt.6100400. Epub 2007 Oct 24.

Abstract

Nanotechnology is the understanding and control of matter generally in the 1-100 nm dimension range. The application of nanotechnology to medicine, known as nanomedicine, concerns the use of precisely engineered materials at this length scale to develop novel therapeutic and diagnostic modalities. Nanomaterials have unique physicochemical properties, such as ultra small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials of the same composition. These properties can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents.

摘要

纳米技术是对尺寸通常在1到100纳米范围内的物质的认知与操控。纳米技术在医学上的应用,即纳米医学,涉及在此长度尺度上使用精确设计的材料来开发新型治疗和诊断方法。纳米材料具有独特的物理化学性质,如超小尺寸、大的表面积与质量比以及高反应活性,这些性质与相同组成的块状材料不同。这些性质可用于克服传统治疗和诊断制剂中发现的一些局限性。

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