CD4细胞计数及CD4/CD8比值与HIV感染相关口腔表现的相关性

Correlation of CD4 counts and CD4/CD8 ratio with HIV-infection associated oral manifestations.

作者信息

Butt F M A, Vaghela V P, Chindia M L

机构信息

Department of Oral and Maxillofacial Surgery, College of Health Sciences, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.

出版信息

East Afr Med J. 2007 Aug;84(8):383-8. doi: 10.4314/eamj.v84i7.9546.

DOI:10.4314/eamj.v84i7.9546

PMID:17970007

Abstract

BACKGROUND

The relationship between oral lesions arising from HIV infection and CD4/CD8 cell ratios is of relevance in clinical assessment of immune suppression.

OBJECTIVE

To correlate the prevalence of oral manifestations arising from HIV infection and the levels of CD4/CD8 cell ratios.

DESIGN

A cross-sectional study.

SETTING

Kenyatta National Hospital, Nairobi, Kenya.

SUBJECTS

Two hundred and seven HIV-infected patients in medical wards were recruited in the study.

RESULTS

Seventy eight (37.7%) were male and 129 (62.3%) female, with an age range of 18-73 years (mean=34.81 years). Oral manifestations encountered with highest prevalence in the oral cavity included: hyperplastic candidosis (labial mucosa) 15%, erythematous candidosis (gingival) 5%, angular cheilitis 32.4%, herpes simplex (corner of the mouth) 0.5%, persistent oral ulceration (labial mucosa) 0.5%, Parotid enlargement 2% and Kaposis sarcoma (hard/soft palate) 2.9%.

CONCLUSION

The prevalence of oral manifestations was higher with low CD4 count <200 cell/mm3 and mean CD4/CD8<0.39(95%CI 0.32-0.48).

摘要

背景

HIV感染引起的口腔病变与CD4/CD8细胞比值之间的关系在免疫抑制的临床评估中具有相关性。

目的

将HIV感染引起的口腔表现患病率与CD4/CD8细胞比值水平相关联。

设计

一项横断面研究。

地点

肯尼亚内罗毕肯雅塔国家医院。

研究对象

招募了207名在内科病房的HIV感染患者参与该研究。

结果

78名（37.7%）为男性，129名（62.3%）为女性，年龄范围为18至73岁（平均=34.81岁）。口腔中患病率最高的口腔表现包括：增生性念珠菌病（唇黏膜）15%、红斑性念珠菌病（牙龈）5%、口角炎32.4%、单纯疱疹（嘴角）0.5%、持续性口腔溃疡（唇黏膜）0.5%、腮腺肿大2%和卡波西肉瘤（硬/软腭）2.9%。