Therapeutic effects of glyprolines (PGP, GP, and PG) in rats with stress-induced behavioral disorders.
作者信息
Kopylova G N, Bakaeva Z V, Badmaeva S E, Umarova B A, Samonina G E, Guseva A A
机构信息
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
出版信息
Bull Exp Biol Med. 2007 Feb;143(2):167-70. doi: 10.1007/s10517-007-0040-z.
PMID:17970191
Abstract
Experiments on male outbred albino rats showed that stress (10-min swimming) increased anxiety and inhibited orientation and exploratory activities. Poststress (15 min after the end of swimming) intranasal administration of peptides Pro-Gly-Pro and Gly-Pro in a dose of 3.7 micromol/kg prevented stress-induced behavioral disorders. This effect persisted for 3 h.
摘要
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