低级别子宫内膜间质肉瘤（LGESS）晚期复发的管理：来曲唑治疗
Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole.
作者信息
Krauss K, Bachmann C, Hartmann J T, Siegmann K, Sotlar K, Wallwiener D, Huober J
机构信息
Department of Obstetrics and Gynecology, Eberhard-Karls-University Tuebingen, Calwestr. 7, D-72076 Tuebingen, Germany.
出版信息
Anticancer Res. 2007 Sep-Oct;27(5B):3477-80.
Low grade endometrial stromal sarcoma (LGESS) is a rare disease. LGESS usually expresses steroidal receptors and is regarded to be hormone-sensitive. Due to the rarity of the tumor, only few case series have been published so far. Here, we report the case of a 36-year-old woman who underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy for a G1 LGESS in 1991. Twelve years later she presented to us with pelvic and peritoneal masses. The patient was treated with letrozole achieving a partial response which is lasting 39 months. Treatment is ongoing. Aromatase inhibitors represent an interesting treatment option for LGESS.
低级别子宫内膜间质肉瘤（LGESS）是一种罕见疾病。LGESS通常表达甾体受体，被认为对激素敏感。由于该肿瘤罕见，迄今为止仅发表了少数病例系列报道。在此，我们报告一例36岁女性的病例，该患者于1991年因G1级LGESS接受了腹式子宫切除术、双侧输卵管卵巢切除术及辅助放疗。12年后，她因盆腔和腹膜肿块前来就诊。该患者接受来曲唑治疗，取得了部分缓解，且持续了39个月。治疗仍在进行中。芳香化酶抑制剂是LGESS一种值得关注的治疗选择。
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