用于制备吡咯并[2',3':3,4]吡咯并[1,2-a]苯并咪唑的甲亚胺叶立德的分子内环加成反应。
Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles.
作者信息
Meng Liping, Fettinger James C, Kurth Mark J
机构信息
Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.
出版信息
Org Lett. 2007 Nov 22;9(24):5055-8. doi: 10.1021/ol702301n. Epub 2007 Nov 1.
PMID:17973485
Abstract
The parent pyrrolidino[2',3':3,4]pyrrolidino[1,2-a]benzimidazole heterocycle as well as a series of novel analogues have been synthesized utilizing a microwave-assisted intramolecular cycloaddition of azomethine ylides as the key transformation. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.
摘要
母体吡咯烷并[2',3':3,4]吡咯烷并[1,2-a]苯并咪唑杂环以及一系列新型类似物已通过微波辅助的甲亚胺叶立德分子内环加成反应作为关键转化步骤合成出来。添加了多种不同的基团以探索该反应的适用范围，并为生物筛选提供一些新化合物。
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