Birth of a healthy boy after fertilization of cryopreserved oocytes with cryopreserved testicular spermatozoa from a man with nonmosaic Klinefelter syndrome.

OBJECTIVE

To report the first birth with frozen spermatozoa and frozen oocytes in a case of nonmosaic Klinefelter syndrome.

DESIGN

Case report.

SETTING

Private IVF clinics and a university hospital.

PATIENT(S): A 32-year-old woman and a 33-year-old man.

INTERVENTION(S): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection.

MAIN OUTCOME MEASURE(S): Assessment of fertilization and chromosomal analysis of newborn child.

RESULT(S): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46,XY) boy.

CONCLUSION(S): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes.