Wei L, Lang C C, Sullivan F M, Boyle P, Wang J, Pringle S D, MacDonald T M
Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Heart. 2008 Sep;94(9):1141-6. doi: 10.1136/hrt.2007.123612. Epub 2007 Nov 5.
To investigate the effect of distance between home and acute hospital on mortality outcome of patients experiencing an incident myocardial infarction (MI).
Cohort study using a record linkage database.
Tayside, Scotland, UK.
10,541 patients with incident acute MI between 1994 and 2003 were identified from Tayside hospital discharge data and from death certification data.
MI mortality in the community, all-cause mortality in hospital and all-cause mortality during follow-up.
4133 subjects died following incident MI in the community (that is, were not hospitalised), 6408 patients survived to be hospitalised and 1010 of these (15.8%) died in hospital. Of 5398 discharged from hospital, 1907 (35.3%) died during a median of 3.2 years of follow-up. After adjustment for rurality and other known risk factors, distance between home and admitting hospital was significantly associated with increased mortality both before hospital admission (adjusted odds ratio (OR), 2.05, 95% CI 1.00 to 4.21 for >9 miles and 1.46, 1.09 to 1.95 for 3-9 miles when compared to <3 miles) and after hospitalisation (adjusted hazard ratio (HR) 1.90, 1.19 to 3.02 and 1.27, 0.96 to 1.68). However, there was no effect of distance on in-hospital mortality (adjusted OR 0.95, 0.45 to 2.03 and 1.02, 0.66 to 1.58).
The distance between home and hospital of admission may predict mortality in subjects experiencing a first acute MI. This association was found both before and after hospitalisation. Further studies are needed to explore the reasons for this association. However these data provide support for policies that locate services for acute MI closer to where patients live.
研究家庭与急症医院之间的距离对首次发生心肌梗死(MI)患者死亡率的影响。
使用记录链接数据库的队列研究。
英国苏格兰泰赛德。
从泰赛德医院出院数据和死亡证明数据中识别出1994年至2003年间首次发生急性心肌梗死的10541例患者。
社区心肌梗死死亡率、住院期间全因死亡率和随访期间全因死亡率。
4133名受试者在社区发生心肌梗死后死亡(即未住院),6408名患者存活并住院,其中1010名(15.8%)在医院死亡。在5398名出院患者中,1907名(35.3%)在中位随访3.2年期间死亡。在对农村地区和其他已知风险因素进行调整后,家庭与收治医院之间的距离与入院前死亡率增加显著相关(调整后的优势比(OR),与<3英里相比,>9英里时为2.05,95%可信区间为1.00至4.21;3 - 9英里时为1.46,1.09至1.95),以及住院后(调整后的风险比(HR)为1.90,1.19至3.02;1.27,0.96至1.68)。然而,距离对住院死亡率没有影响(调整后的OR为0.95,0.45至2.03;1.02,0.66至1.58)。
家庭与收治医院之间的距离可能预测首次发生急性心肌梗死患者的死亡率。这种关联在住院前后均被发现。需要进一步研究以探索这种关联的原因。然而,这些数据为将急性心肌梗死服务设置在更靠近患者居住地点的政策提供了支持。