Dougal Sonya, Phelps Elizabeth A, Davachi Lila
New York University, New York, New York 10003, USA.
Cogn Affect Behav Neurosci. 2007 Sep;7(3):233-42. doi: 10.3758/cabn.7.3.233.
Recent neuroimaging results suggest that distinct regions within the medial temporal lobe (MTL) may differentially support the episodic encoding of item and relational information for nonemotional stimuli . The present study was designed to assess whether these findings generalize to emotional stimuli. Behaviorally, we found that emotion reduced item recognition accuracy but did not reliably affect relational memory. fMRI analyses revealed that neutral and emotional words elicited distinct activation patterns within MTL regions predictive of subsequent memory. Consistent with previous findings for neutral words, hippocampal activation predicted later relational memory, whereas activation in the perirhinal cortex predicted successful item recognition. However, for emotional words, activation in the amygdala, hippocampus, and posterior parahippocampal cortex predicted item recognition only. These data suggest that MTL regions differentially support encoding of neutral and emotional stimuli.
近期的神经影像学研究结果表明，内侧颞叶（MTL）内的不同区域可能对非情感刺激的项目和关系信息的情景编码有不同的支持作用。本研究旨在评估这些发现是否适用于情感刺激。行为学上，我们发现情感会降低项目识别的准确性，但对关系记忆没有可靠影响。功能磁共振成像分析显示，中性词和情感词在MTL区域内引发了不同的激活模式，这些模式可预测后续记忆。与之前对中性词的研究结果一致，海马体激活可预测后期的关系记忆，而嗅周皮质的激活则可预测项目识别成功。然而，对于情感词，杏仁核、海马体和海马旁回后部皮质的激活仅能预测项目识别。这些数据表明，MTL区域对中性和情感刺激的编码有不同的支持作用。
