共调控基因启动子中基序的发现。

Discovery of motifs in promoters of coregulated genes.

作者信息

Sand Olivier, van Helden Jacques

机构信息

Service de Conformation des Macromolécules, Biologiques et de Bioinformatiques, Université Libre de Bruxelles, Belgium.

出版信息

Methods Mol Biol. 2007;395:329-48. doi: 10.1007/978-1-59745-514-5_21.

DOI:10.1007/978-1-59745-514-5_21

PMID:17993684

Abstract

We present a method to predict cis-acting elements by detecting over-represented motifs in promoters of a set of coregulated genes (single-genome, multigenes approach). The method has been used successfully to detect regulating elements in bacteria and yeast. It can be used with higher organisms as well, but with a loss in reliability of the predictions. A web interface is available at the Regulatory Sequence Analysis Tools site (http://rsat.scmbb.ulb.ac.be/rsat/).

摘要

我们提出了一种通过检测一组共调控基因（单基因组、多基因方法）启动子中过度出现的基序来预测顺式作用元件的方法。该方法已成功用于检测细菌和酵母中的调控元件。它也可用于高等生物，但预测的可靠性会有所降低。可在调控序列分析工具网站（http://rsat.scmbb.ulb.ac.be/rsat/）上使用网络界面。