Afiyatullov Shamil Sh, Kalinovsky Anatoly I, Antonov Alexandr S, Ponomarenko Ludmila P, Dmitrenok Pavel S, Aminin Dmitry L, Krasokhin Vladimir B, Nosova Valentina M, Kisin Alexandr V
Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok, Russian Federation.
J Nat Prod. 2007 Dec;70(12):1871-7. doi: 10.1021/np070319y. Epub 2007 Nov 16.
Eight new triterpene glycosides, erylosides R ( 1), S ( 2), T ( 3), U ( 4), F 5-F 7 ( 5- 7), and V ( 8), were isolated from the sponge Erylus goffrilleri collected near Arresife-Seko Reef (Cuba). Structures of 1 and 2 were determined as the corresponding monosides having aglycons related to penasterol with additional oxidation and methylation patterns in their side chains. Eryloside T ( 3) was structurally identified as the Delta (7)-isomer of 1, containing an unusual (14-->9)-lactone ring in the tetracyclic aglycon moiety, and eryloside U ( 4) was shown to be the 7,8-epoxide of 3. Erylosides F 5-F 7 ( 5- 7) and V ( 8) contain new variants of carbohydrate chains with two ( 5- 7) and three ( 8) sugar units, respectively.
从采集于古巴阿雷西费-塞科礁附近的海绵Erylus goffrilleri中分离出8种新的三萜糖苷，即erylosides R（1）、S（2）、T（3）、U（4）、F 5 - F 7（5 - 7）和V（8）。1和2的结构被确定为具有与甾醇相关苷元的相应单糖苷，其侧链具有额外的氧化和甲基化模式。Eryloside T（3）在结构上被鉴定为1的Δ（7）-异构体，在四环苷元部分含有一个不寻常的（14→9）-内酯环，而eryloside U（4）被证明是3的7,8-环氧化物。Erylosides F 5 - F 7（5 - 7）和V（8）分别含有具有两个（5 - 7）和三个（8）糖单元的碳水化合物链的新变体。
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