Takashina Masaki, Ueyama Hiroshi, Sugano Nobuhiko, Nakata Seizo, Mashimo Takashi
Surgical Center, Osaka University Hospital, 2-15 Yamadaoka, Suita, 565-0871, Japan.
J Anesth. 2007;21(4):459-66. doi: 10.1007/s00540-007-0545-7. Epub 2007 Nov 1.
In total hip arthroplasty (THA), there is a high risk of bone marrow embolism during femoral prosthesis insertion. However, the incidence during acetabular prosthesis insertion has received less attention. The first goal of this study was to determine the incidence of bone marrow embolism associated with acetabular prosthesis insertion. The second goal was to evaluate the effects of intramedullary decompression of the acetabulum in suppressing bone marrow embolism.
To achieve the first goal, we evaluated the effects of prosthesis insertion on the incidence of bone marrow embolism, and on respiratory and cardiovascular dynamics. For the evaluation of bone marrow embolism, images obtained by transesophageal echocardiography were rated using Pitto's classification. To achieve the second goal, patients undergoing THA with a one-piece type acetabular prosthesis were divided into a control group and an acetabulum-decompression group, and the effects of insertion were analyzed in the same fashion.
In the 150 patients in the study, bone marrow embolism was rated as grade 0 in 9, grade 1 in 46, grade 2 in 61, and grade 3 in 34 patients. Patients rated as grade 2 and 3 exhibited significant reductions in blood pressure and Pa(O) (2) 5 min after acetabular prosthesis insertion. The results of multivariate analysis suggested that the incidence of bone marrow embolism was higher for the one-piece type prosthesis than for the two-piece type. Among the 60 patients who underwent THA with a one-piece type prosthesis, the incidence of bone marrow embolism was significantly lower in the decompression group.
As there are increasing indications for one-piece type acetabular prostheses in Japan, we must pay attention to the possibility of bone marrow embolism, not only during femoral prosthesis insertion but also during acetabular prosthesis insertion.
在全髋关节置换术(THA)中,股骨假体植入过程中发生骨髓栓塞的风险很高。然而,髋臼假体植入过程中的发生率较少受到关注。本研究的首要目标是确定与髋臼假体植入相关的骨髓栓塞发生率。第二个目标是评估髋臼髓内减压在抑制骨髓栓塞方面的效果。
为实现首要目标,我们评估了假体植入对骨髓栓塞发生率以及呼吸和心血管动力学的影响。对于骨髓栓塞的评估,经食管超声心动图获得的图像采用皮托分类法进行分级。为实现第二个目标,接受一体式髋臼假体THA的患者被分为对照组和髋臼减压组,并以相同方式分析植入效果。
在该研究的150例患者中,9例骨髓栓塞评分为0级,46例为1级,61例为2级,34例为3级。评分为2级和3级的患者在髋臼假体植入后5分钟血压和动脉血氧分压(Pa[O₂])显著降低。多因素分析结果表明,一体式假体的骨髓栓塞发生率高于两件式假体。在接受一体式假体THA的60例患者中,减压组的骨髓栓塞发生率显著较低。
由于日本一体式髋臼假体的适应证越来越多,我们不仅在股骨假体植入过程中,而且在髋臼假体植入过程中都必须注意骨髓栓塞的可能性。