Kloska S P, Husstedt I W, Schlegel P M, Anneken K, Evers S, Fischbach R, Heindel W
Institut für Klinische Radiologie, Universitätsklinikum Münster, Münster.
Rofo. 2008 Jan;180(1):21-9. doi: 10.1055/s-2007-963567. Epub 2007 Nov 16.
The spectrum of pathology affecting the central nervous system (CNS) in patients suffering from acquired immunodeficiency syndrome (AIDS) includes not only the human immunodeficiency virus (HIV) infection itself but also opportunistic infections and tumors secondary to AIDS. Despite progress in antiretroviral therapy and the subsequent decrease in the incidence of associated diseases, opportunistic infections and tumors secondary to the HIV infection continue to be the limiting factor in terms of survival with AIDS. Therefore, the therapeutic aim is permanent antiretroviral therapy as well as early diagnosis and treatment of opportunistic infections. Magnetic resonance imaging is often the diagnostic method of choice in suspected CNS pathology of HIV patients. In the following, the typical clinical and radiological features of several AIDS-related pathologies are presented and discussed.
获得性免疫缺陷综合征(AIDS)患者中枢神经系统(CNS)受影响的病理谱不仅包括人类免疫缺陷病毒(HIV)感染本身,还包括继发于AIDS的机会性感染和肿瘤。尽管抗逆转录病毒疗法取得了进展,相关疾病的发病率随后有所下降,但继发于HIV感染的机会性感染和肿瘤仍然是AIDS患者生存的限制因素。因此,治疗目标是进行长期抗逆转录病毒治疗以及对机会性感染进行早期诊断和治疗。磁共振成像通常是疑似HIV患者中枢神经系统病理的首选诊断方法。以下将介绍并讨论几种与AIDS相关病理的典型临床和放射学特征。