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预防母婴传播项目参与机会的错失:奈韦拉平的简便性未必能带来最佳接受度,一项定性研究

Missed opportunities for participation in prevention of mother to child transmission programmes: simplicity of nevirapine does not necessarily lead to optimal uptake, a qualitative study.

作者信息

Nkonki Lungiswa L, Doherty Tanya M, Hill Zelee, Chopra Mickey, Schaay Nikki, Kendall Carl

机构信息

Health Systems Research Unit, Medical Research Council, Cape Town, South Africa.

出版信息

AIDS Res Ther. 2007 Nov 22;4:27. doi: 10.1186/1742-6405-4-27.

Abstract

BACKGROUND

The objective of this study was to examine missed opportunities for participation in a prevention of mother-to-child transmission (PMTCT) programme in three sites in South Africa. A rapid anthropological assessment was used to collect in-depth data from 58 HIV-positive women who were enrolled in a larger cohort study to assess mother-to-child HIV transmission. Semi-structured interviews were conducted with the women in order to gain an understanding of their experiences of antenatal care and to identify missed opportunities for participation in PMTCT.

RESULTS

15 women actually missed their nevirapine not because of stigma and ignorance but because of health systems failures. Six were not tested for HIV during antenatal care. Two were tested but did not receive their results. Seven were tested and received their results, but did not receive nevirapine. Health Systems failure for these programme leakages ranged from non-availability of counselors, supplies such as HIV test kits, consent forms, health staff giving the women incorrect instructions about when to take the tablet and health staff not supplying the women with the tablet to take.

CONCLUSION

HIV testing enables access to PMTCT interventions and should therefore be strengthened. The single dose nevirapine regimen is simple to implement but the all or nothing nature of the regimen may result in many missed opportunities. A short course dual or triple drug regimen could increase the effectiveness of PMTCT programmes.

摘要

背景

本研究的目的是调查南非三个地点在预防母婴传播(PMTCT)项目中存在的参与机会缺失情况。采用快速人类学评估方法,从58名参与一项更大规模队列研究以评估母婴HIV传播情况的HIV阳性女性中收集深入数据。对这些女性进行了半结构化访谈,以了解她们的产前护理经历,并确定参与PMTCT存在的机会缺失情况。

结果

15名女性实际错过奈韦拉平并非因为耻辱感和无知,而是由于卫生系统故障。6名女性在产前护理期间未接受HIV检测。2名女性接受了检测但未收到检测结果。7名女性接受了检测并收到了结果,但未获得奈韦拉平。这些项目漏洞导致的卫生系统故障包括咨询人员不足、HIV检测试剂盒等用品短缺、同意书缺失、医护人员给女性关于服药时间的错误指示以及医护人员未给女性提供药物服用。

结论

HIV检测有助于获得PMTCT干预措施,因此应予以加强。单剂量奈韦拉平方案易于实施,但该方案的全有或全无性质可能导致许多机会缺失。短期双药或三药方案可能会提高PMTCT项目的有效性。

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