杀死还是抑制：这是凋亡蛋白酶激活因子-1面临的新问题。

To kill or to arrest: that is the new question for Apaf-1.

作者信息

Sanchez-Olea Roberto, Yuan Junying

机构信息

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Mol Cell. 2007 Nov 30;28(4):520-1. doi: 10.1016/j.molcel.2007.11.007.

DOI:10.1016/j.molcel.2007.11.007

PMID:18042448

Abstract

In this issue of Molecular Cell, Zermati et al. (2007) report that Apaf-1 is essential for the DNA damage-induced intra-S phase checkpoint response. This new role for Apaf-1 is unrelated to its proapoptotic function but is evolutionarily conserved in Ced-4.

摘要

在本期的《分子细胞》杂志中，泽尔马蒂等人（2007年）报道称，凋亡蛋白酶激活因子-1（Apaf-1）对于DNA损伤诱导的S期内检验点反应至关重要。Apaf-1的这一新功能与其促凋亡功能无关，但在CED-4中具有进化保守性。