变色菌素R - T，来自海洋海绵Spongia sp.的新型倍半萜类化合物

Metachromins R--T, new sesquiterpenoids from marine sponge Spongia sp.

作者信息

Takahashi Yohei, Yamada Mika, Kubota Takaaki, Fromont Jane, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, sapporo 060-0812, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2007 Dec;55(12):1731-3. doi: 10.1248/cpb.55.1731.

DOI:10.1248/cpb.55.1731

PMID:18057748

Abstract

Three new sesquiterpenoids, metachromins R--T (1--3), have been isolated from an Okinawan marine sponge Spongia sp. The structures and stereochemistry of 1--3 were elucidated on the basis of the spectroscopic data. Metachromins S (2) and T (3) showed modest cytotoxicity.

摘要

从冲绳海洋海绵Spongia sp.中分离出了三种新的倍半萜类化合物，变色菌素R - T（1 - 3）。根据光谱数据阐明了1 - 3的结构和立体化学。变色菌素S（2）和T（3）表现出适度的细胞毒性。