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埃及蜂胶对低密度脂蛋白氧化修饰敏感性的影响及其抗病毒活性,特别强调其化学成分。

Effect of Egyptian propolis on the susceptibility of LDL to oxidative modification and its antiviral activity with special emphasis on chemical composition.

作者信息

Abd El-Hady Faten K, Hegazi Ahmed G, Wollenweber Eckhard

机构信息

Department of Chemistry of Natural Products, National Research Center Dokki, Giza, Egypt.

出版信息

Z Naturforsch C J Biosci. 2007 Sep-Oct;62(9-10):645-55. doi: 10.1515/znc-2007-9-1004.

Abstract

The antioxidant activity of eight Egyptian propolis samples from different localities was evaluated by the antioxidative potential and capacity of the DPPH-ESR signal, superoxide anion generated in the xanthine-xanthine oxidase (XOD) system and low density lipoprotein (LDL) peroxidation assay. As, F, Is and D samples showed the highest antioxidative capacity and potential, respectively. The El, IsR, Is, D and So samples exhibited highly significant antioxidant activity in the XOD system and in LDL peroxidation assays. The antiviral activity of propolis samples was investigated. They showed variations in their activity; sample D induced the highest antiviral activity against Newcastle disease virus and infectious bursal disease virus. 42 Polyphenolic compounds were identified by HPLC; 13 aromatic acids, esters and alcohols were present, 29 flavonoids were identified, 6 of them being new to propolis.

摘要

通过二苯基苦味酰基自由基(DPPH)-电子自旋共振(ESR)信号的抗氧化潜力和能力、黄嘌呤-黄嘌呤氧化酶(XOD)系统中产生的超氧阴离子以及低密度脂蛋白(LDL)过氧化试验,对来自不同地区的八个埃及蜂胶样品的抗氧化活性进行了评估。As、F、Is和D样品分别表现出最高的抗氧化能力和潜力。El、IsR、Is、D和So样品在XOD系统和LDL过氧化试验中表现出高度显著的抗氧化活性。对蜂胶样品的抗病毒活性进行了研究。它们的活性存在差异;样品D对新城疫病毒和传染性法氏囊病病毒诱导出最高的抗病毒活性。通过高效液相色谱法(HPLC)鉴定出42种多酚化合物;存在13种芳香酸、酯和醇,鉴定出29种黄酮类化合物,其中6种是蜂胶中的新成分。

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