Fernández Pedro Lorenzo
An R Acad Nac Med (Madr). 2007;124(1):189-200; discussion 200-1.
Based on Nanotechnology methods, Nanomedicine and Nanotecnology will obtain significant advances in areas such as Diagnostic, Regenerative Medicine and pharmacological Therapeutics. With nanotechnology-based drug delivery systems,important improvement on pharmacokinetics of drugs will take place, due to increased solubility, protection against decrease in drug effects due to excessive metabolism and subsequent increase of bioavailability. Improvement on pharmacodynamic parameters will occur also due to increased drug concentration in target tissues. Also the use of Nanotechnology in the modern pharmacology will serve for a more accurate control of doses, which will decrease significantly drug toxicity.
基于纳米技术方法,纳米医学和纳米技术将在诊断、再生医学和药物治疗等领域取得重大进展。借助基于纳米技术的药物递送系统,药物的药代动力学将得到重要改善,这是因为药物溶解度增加、可防止因过度代谢导致药物效果降低以及随后生物利用度提高。由于靶组织中药物浓度增加,药效学参数也将得到改善。此外,纳米技术在现代药理学中的应用将有助于更精确地控制剂量,这将显著降低药物毒性。