Beasley David W C, Lewthwaite Penny, Solomon Tom
University of Texas Medical Branch, Department of Microbiology and Immunology, Galveston, TX 77555-0609, USA.
Expert Opin Biol Ther. 2008 Jan;8(1):95-106. doi: 10.1517/14712598.8.1.95.
Japanese encephalitis (JE) is a significant cause of human morbidity and mortality throughout Asia. Vaccines for JE have been available for many years and their use has been effective in reducing the incidence of JE disease in several countries but, as disease incidence has decreased, concerns regarding adverse events following immunisation have increased.
To review existing JE vaccines and new candidates in advanced preclinical or clinical evaluation.
The review primarily covers published and some unpublished literature from the past decade describing current use of approved JE vaccines in various parts of the world, and advanced development and clinical testing of alternative vaccine candidates.
RESULTS/CONCLUSION: There is a clear need for additional licensing of existing or new JE vaccines. Several promising candidates are currently in use or completing clinical trials.
日本脑炎（乙脑）是亚洲地区人类发病和死亡的重要原因。乙脑疫苗已上市多年，在一些国家使用疫苗有效降低了乙脑发病率，但随着发病率下降，对免疫接种后不良事件的担忧增加。
综述现有的乙脑疫苗以及处于临床前或临床评估后期的新候选疫苗。
本综述主要涵盖过去十年已发表和部分未发表的文献，这些文献描述了世界各地区批准使用的乙脑疫苗的当前使用情况，以及替代候选疫苗的前期开发和临床试验情况。
结果/结论：显然需要对现有或新型乙脑疫苗进行更多许可。目前有几种有前景的候选疫苗正在使用或即将完成临床试验。
Zotero 插件