组织中血管的三维光声成像。

Three-dimensional photoacoustic imaging of blood vessels in tissue.

作者信息

Hoelen C G, de Mul F F, Pongers R, Dekker A

出版信息

Opt Lett. 1998 Apr 15;23(8):648-50. doi: 10.1364/ol.23.000648.

DOI:10.1364/ol.23.000648

Abstract

We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ~1 cm . The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter (200 microm). The depth resolution is ~10 microm.

摘要

我们将光声技术用作一种组织断层成像技术，用于检测血液浓度，例如肿瘤周围的血管生成情况。我们使用532纳米的光对高散射样品中的血管进行成像，成像深度约为1厘米。样品为真实组织（鸡胸肉）或10%稀释的10%英脱利匹特。血液流经尼龙毛细管。聚偏二氟乙烯（PVdF）压电探测器以表面扫描模式使用。我们通过对玻璃板上单个红细胞进行光声检测来证明该技术的灵敏度。横向分辨率受探测器直径（200微米）限制。深度分辨率约为10微米。