Curtis Kevin M, Henriques Horace F, Fanciullo Gilbert, Reynolds Cecily M, Suber Freeman
Departments of Emergency Medicine, Dartmouth-Hitchcock, Medical Center, Lebanon, New Hampshire, USA.
J Trauma. 2007 Oct;63(4):819-26. doi: 10.1097/01.ta.0000240979.31046.98.
In the past two decades, a number of reports have identified inadequate treatment of pain among emergency department patients. No study has evaluated the frequency or effectiveness of early analgesia in the trauma patient. The objective of this study was to determine the effect of a protocol-driven pain management scheme on time to initiation of analgesia among trauma patients.
A fentanyl-based protocol was developed with patients being assigned to one of three treatment arms based on hemodynamics and Glasgow Coma Scale (GCS) score. Using an institutional review board-approved before and after study design, patients over the age of 14 and meeting trauma system activation criteria at the Dartmouth-Hitchcock Medical Center were eligible. Results were compared with a retrospective chart review of eligible patients treated during a matched preprotocol time period in 2002. The primary outcome measure was time to initiation of analgesia. Secondary outcome measures included (1) the proportion of patients receiving their first analgesia dose within 30 minutes, (2) the number of patients receiving multiple doses of analgesia in the trauma bay, and (3) adverse events. Pain level was assessed using either a Numeric Pain Scale (for patients with a GCS score of 15) or a Behavioral Pain Assessment Scale (GCS score <15).
Implementation of the protocol resulted in a decrease in the mean time to initiation of analgesia from 53.61 minutes +/- 6.88 minutes to 27.94 minutes +/- 3.34 minutes (p = 0.001). The protocol also increased the percentage of patients receiving analgesia within the first 30 minutes of arrival from 44.4% to 74.6% (p < 0.001). There were no differences between the two groups in terms of baseline characteristics or adverse events.
The implementation of a fentanyl-based pain management protocol resulted in a marked reduction in time to initial analgesia among trauma patients. There was no evidence of an increase in adverse events. This tool has the potential to be easily extrapolated and applied to other trauma systems.
在过去二十年中,多项报告指出急诊科患者的疼痛治疗不充分。尚无研究评估创伤患者早期镇痛的频率或效果。本研究的目的是确定基于方案的疼痛管理方案对创伤患者开始镇痛时间的影响。
制定了一项基于芬太尼的方案,根据血流动力学和格拉斯哥昏迷量表(GCS)评分将患者分配到三个治疗组之一。采用经机构审查委员会批准的前后对照研究设计,年龄在14岁以上且符合达特茅斯-希区柯克医疗中心创伤系统启动标准的患者符合条件。将结果与2002年匹配的方案前时间段内接受治疗的符合条件患者的回顾性病历审查结果进行比较。主要结局指标是开始镇痛的时间。次要结局指标包括:(1)在30分钟内接受首剂镇痛药物的患者比例;(2)在创伤病房接受多剂镇痛药物的患者数量;(3)不良事件。使用数字疼痛量表(适用于GCS评分为15分的患者)或行为疼痛评估量表(GCS评分<15分)评估疼痛程度。
该方案的实施使开始镇痛的平均时间从53.61分钟±6.88分钟降至27.94分钟±3.34分钟(p = 0.001)。该方案还使到达后30分钟内接受镇痛的患者百分比从44.4%提高到74.6%(p<0.001)。两组在基线特征或不良事件方面无差异。
基于芬太尼的疼痛管理方案的实施使创伤患者开始初始镇痛的时间显著缩短。没有证据表明不良事件增加。该工具有可能很容易地推广并应用于其他创伤系统。