Ishii Yosuke, Nitta Takashi
Nippon Medical School, Tokyo, Japan.
J Interv Card Electrophysiol. 2007 Dec;20(3):109-12. doi: 10.1007/s10840-007-9179-9.
Atrial fibrillation (AF) is commonly associated with rheumatic valve disease. The dilated left atrium, degeneration of the left atrial myocardium, and elevated atrial pressure all contribute to perpetuation of AF. Over the past decade, the Maze procedure has evolved into the gold standard of treatment for medically refractory AF. The atrial incisions of the Maze procedure are designed to block potential macroreentrant pathways and propagation of microreentrant wavelets. The dilated left atrium and degeneration of the atrial myocardium caused by rheumatic inflammation participate in recurrence of postoperative AF years after surgery. Increased inflammatory response correlates with occurrence of postoperative AF. Pre- and postoperative anti-inflammatory therapy might be effective in decreasing the recurrence of AF in rheumatic heart disease patients. This article reviews the mechanisms of AF and surgical procedures in rheumatic valve disease.
心房颤动(AF)通常与风湿性瓣膜病相关。左心房扩大、左心房心肌退变以及心房压力升高均促使房颤持续存在。在过去十年中,迷宫手术已发展成为药物难治性房颤的治疗金标准。迷宫手术的心房切口旨在阻断潜在的大折返通路和微折返小波的传播。风湿性炎症导致的左心房扩大和心房心肌退变参与了术后数年房颤的复发。炎症反应增强与术后房颤的发生相关。术前和术后抗炎治疗可能有效降低风湿性心脏病患者房颤的复发率。本文综述了风湿性瓣膜病中房颤的机制及外科手术方法。