Das Sanjita, Sasmal Dinakar, Basu Saumya Priya
Birla Institute of Technology and Sciences, Mesra, Ranchi 835215, Jharkhand, India.
J Ethnopharmacol. 2008 Feb 28;116(1):198-203. doi: 10.1016/j.jep.2007.11.034. Epub 2007 Nov 29.
Nyctanthes arbortristis Linn is a well-documented plant. It is evident from literature and previous investigations that Nyctanthes arbortristis possesses anti-inflammatory and analgesic activity. In the present study arbortristoside-A has been isolated from the ethanolic extract of its seeds. The structure of the isolated compound was determined by chemical reactions and spectroscopic methods. Arbortristoside-A was found to possess significant and dose-dependent anti-inflammatory and antinociceptive activity. It seems arbortristoside-A inhibited the histamine, serotonin and carrageenan-induced edema suggesting its inhibiting effect on carrageenan, arachidonic acid, histamine and serotonin-induced edema suggesting its anti-inflammatory activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. The analgesic activity of arbortristoside-A may be due to the inhibition of the action of prostaglandin.
夜花树（Nyctanthes arbortristis Linn）是一种有充分文献记载的植物。从文献和先前的研究中可以明显看出，夜花树具有抗炎和镇痛活性。在本研究中，从其种子的乙醇提取物中分离出了arbortristoside - A。通过化学反应和光谱方法确定了分离出的化合物的结构。发现arbortristoside - A具有显著的剂量依赖性抗炎和抗伤害感受活性。arbortristoside - A似乎抑制了组胺、5-羟色胺和角叉菜胶诱导的水肿，表明其对角叉菜胶、花生四烯酸、组胺和5-羟色胺诱导的水肿具有抑制作用，提示其抗炎活性可能归因于对前列腺素、组胺和5-羟色胺的抑制作用。arbortristoside - A的镇痛活性可能归因于对前列腺素作用的抑制。
