Di Betta Ernesto, Mittempergher Francesco, Nascimbeni Riccardo, Salerni Bruno
Cattedra di Chirurgia Generale, Università degli Studi di Brescia, UO 1 Chirurgia Generale, Ple Spedali Civili 2, 25133 Brescia, Italy.
Obes Surg. 2008 Feb;18(2):182-6. doi: 10.1007/s11695-007-9293-x. Epub 2008 Jan 8.
In super-super obese (SSO) patients [body mass index (BMI) superior of 60 kg/m2] results of bariatric surgery are still controversial. This study evaluated safety and efficacy of open duodenal switch associated with transitory vertical gastroplasty (DS-TVG) after 8 years of follow-up.
A prospective observational study of 32 SSO patients who underwent an open DS-TVG from January 1999 till March 2006 was performed. Study endpoints included preoperative comorbidities [diabetes, hypertension, and obstructive sleep apnea syndrome (OSAS)], postoperative morbidity and mortality, and long-term results of BMI and percent of excess weight loss (%EWL) (median 48 months).
Results in terms of BMI and %EWL were, respectively, after 12 months, 46.3 +/- 10.2 and 57.1 +/- 9.8; after 36 months (n = 21), 37.5 +/- 7.5 and 73.5 +/- 6.2; and after 84 months (n = 5), 31.7 +/- 2.8 and 76.0 +/- 4.1. With regard to comorbidities, we observed complete control of lipid alterations and type-2 diabetes (suspension therapy within 1 year). All patients with OSAS improved within 1 year without needing domiciliary oxygen therapy. Neither malnutrition nor mortality was observed during the follow-up. Major complications occurred in a total of 5 patients (15.6%): pulmonary embolism (2 cases-9.4%); gastrointestinal bleeding, requiring transfusions (1 case-3.1%); 1 case (3.1%) of abdominal rupture; and 1 case of acute pancreatitis (3.1%). Minor complications occurred in 4 patients (12.5%): 1 case of pneumonia, 1 urinary tract infection, and 2 wound infections.
Although this study evaluated the outcomes of a small series of patients after open DS-TVG, this procedure seems to be safe and effective in obese patients who have a BMI greater than 60 kg/m2. In our opinion, DS-TVG should be considered as a valid surgical option with two staged laparoscopic procedures.
在超级肥胖(体重指数[BMI]超过60kg/m²)患者中,减肥手术的效果仍存在争议。本研究评估了开放性十二指肠转位联合暂时性垂直胃成形术(DS-TVG)在8年随访后的安全性和有效性。
对1999年1月至2006年3月期间接受开放性DS-TVG手术的32例超级肥胖患者进行了一项前瞻性观察研究。研究终点包括术前合并症(糖尿病、高血压和阻塞性睡眠呼吸暂停综合征[OSAS])、术后发病率和死亡率,以及BMI和超重减轻百分比(%EWL)的长期结果(中位随访48个月)。
术后12个月时,BMI和%EWL分别为46.3±10.2和57.1±9.8;36个月时(n = 21),分别为37.5±7.5和73.5±6.2;84个月时(n = 5),分别为31.7±2.8和76.0±4.1。关于合并症,我们观察到脂质异常和2型糖尿病得到完全控制(1年内停止治疗)。所有OSAS患者在1年内病情改善,无需家庭氧疗。随访期间未观察到营养不良和死亡病例。共有5例患者(15.6%)发生了严重并发症:肺栓塞(2例-9.4%);需要输血的胃肠道出血(1例-3.1%);1例(3.1%)腹部破裂;1例急性胰腺炎(3.1%)。4例患者(12.5%)发生了轻微并发症:1例肺炎、1例尿路感染和2例伤口感染。
尽管本研究评估了一小系列开放性DS-TVG术后患者的结局,但该手术在BMI大于60kg/m²的肥胖患者中似乎是安全有效的。我们认为,DS-TVG应被视为一种有效的手术选择,可采用两阶段腹腔镜手术。