微小RNA介导的基因调控系统中复杂性的演变。
Evolution of complexity in miRNA-mediated gene regulation systems.
作者信息
Takuno Shohei, Innan Hideki
机构信息
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
出版信息
Trends Genet. 2008 Feb;24(2):56-9. doi: 10.1016/j.tig.2007.11.002. Epub 2008 Jan 14.
Using Arabidopsis microRNA (miRNA)-mediated gene regulation system as a model, we investigated how complex systems evolve with special attention to selection to maintain the systems. We found that the copy number of miRNA genes within each system is a key factor to determine the complexity of the system, indicating a crucial role of gene duplication to increase the complexity. Furthermore, we show that the mode of selection to maintain the systems depend on their complexity levels.
以拟南芥微小RNA（miRNA）介导的基因调控系统为模型，我们特别关注维持这些系统的选择，研究了复杂系统是如何进化的。我们发现，每个系统内miRNA基因的拷贝数是决定系统复杂性的关键因素，这表明基因复制在增加复杂性方面起着至关重要的作用。此外，我们表明，维持这些系统的选择模式取决于它们的复杂程度。
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