Takuno Shohei, Innan Hideki
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Trends Genet. 2008 Feb;24(2):56-9. doi: 10.1016/j.tig.2007.11.002. Epub 2008 Jan 14.
Using Arabidopsis microRNA (miRNA)-mediated gene regulation system as a model, we investigated how complex systems evolve with special attention to selection to maintain the systems. We found that the copy number of miRNA genes within each system is a key factor to determine the complexity of the system, indicating a crucial role of gene duplication to increase the complexity. Furthermore, we show that the mode of selection to maintain the systems depend on their complexity levels.
以拟南芥微小RNA（miRNA）介导的基因调控系统为模型，我们特别关注维持这些系统的选择，研究了复杂系统是如何进化的。我们发现，每个系统内miRNA基因的拷贝数是决定系统复杂性的关键因素，这表明基因复制在增加复杂性方面起着至关重要的作用。此外，我们表明，维持这些系统的选择模式取决于它们的复杂程度。
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