孤儿核受体对辅助性T细胞17分化的调控：不再只是维甲酸相关孤儿受体γt了。

Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore.

作者信息

Sundrud Mark S, Rao Anjana

机构信息

Department of Pathology, Harvard Medical School, and Immune Disease Institute, Boston, MA 02115, USA.

出版信息

Immunity. 2008 Jan;28(1):5-7. doi: 10.1016/j.immuni.2007.12.006.

DOI:10.1016/j.immuni.2007.12.006

PMID:18199410

Abstract

T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation.

摘要

产生白细胞介素-17的T细胞（辅助性T细胞17）与自身免疫发病机制有关。在本期《免疫》杂志中，Yang等人（2008年）报道，密切相关的孤儿核受体RORα和RORγt共同作用来调节辅助性T（Th）17细胞的分化。