Rupp Richard, Rosenthal Susan L, Stanberry Lawrence R
Sealy Center for Vaccine Development and Department of Pediatrics, University of Texas Medical Branch, Galveston,Texas 77555-1119, USA.
Int J Nanomedicine. 2007;2(4):561-6.
Microbicides are compounds that applied vaginally or rectally, protect the user from sexually transmitted infections. Although no commercial product is yet available, many candidates are under development. A leading candidate, VivaGel (SPL7013 Gel) is the product of nanotechnology. The active ingredient is SPL7013, a dendrimer that was designed specifically with HIV and HSV antiviral activity and human safety in mind. SPL7013 has demonstrated efficacy against human immunodeficiency virus and herpes simplex virus in in vitro and animal models. VivaGel appears to be well tolerated in both animals and humans. This review summarizes the studies of VivaGel and its active ingredient, SPL7013.
杀微生物剂是经阴道或直肠给药、保护使用者免受性传播感染的化合物。尽管尚无商业产品问世,但许多候选产品正在研发中。一种主要的候选产品VivaGel(SPL7013凝胶)是纳米技术的产物。其活性成分是SPL7013,一种专门设计的具有抗HIV和HSV活性且考虑到人体安全性的树枝状大分子。SPL7013已在体外和动物模型中证明对人类免疫缺陷病毒和单纯疱疹病毒有效。VivaGel在动物和人类中似乎都具有良好的耐受性。本综述总结了关于VivaGel及其活性成分SPL7013的研究。