墨西哥人群中成年急性淋巴细胞白血病患者CYP1A1*2A基因多态性的分布情况

Distribution of CYP1A1*2A polymorphism in adult patients with acute lymphoblastic leukemia in a Mexican population.

作者信息

Gallegos-Arreola M P, González-García J R, Figuera L E, Puebla-Pérez A M, Delgado-Lamas J L, Zúñiga-González G M

机构信息

Laboratorio de Genética Molecular, División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México.

出版信息

Blood Cells Mol Dis. 2008 Jul-Aug;41(1):91-4. doi: 10.1016/j.bcmd.2007.12.001. Epub 2008 Jan 18.

DOI:10.1016/j.bcmd.2007.12.001

PMID:18203634

Abstract

The effects of the CYP1A12A genotype on susceptibility to leukemia have received particular attention in recent years because this enzyme plays a central role in the activation of carcinogens. Several polymorphisms at the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We evaluated the role of the CYP1A12A genotype in adults with acute lymphoblastic leukemia (ALL) by genotyping 210 patients and 228 healthy controls from the Mexican population. The frequency of the CC genotype was 8% (18/228) in the control group and 42% (88/210) in ALL patients; the frequency of the CT genotype was 39% (89/228) and 29.5% (62/210), respectively; and that of the TT genotype was 53% (121/228) and 28.5% (60/210), respectively. The odds ratio was 8.4 (95% CI, 4.7-15.5; P < 0.001). These data indicate that the CYP1A1*2A genotype contributes significantly to susceptibility to adult ALL in a sample of the Mexican population.

摘要

近年来，CYP1A12A基因型对白血病易感性的影响受到了特别关注，因为这种酶在致癌物激活过程中起着核心作用。CYP1A1基因座已鉴定出几种多态性，其基因型的群体频率似乎取决于种族。我们通过对来自墨西哥人群的210例急性淋巴细胞白血病（ALL）患者和228例健康对照进行基因分型，评估了CYP1A12A基因型在成人ALL中的作用。对照组中CC基因型的频率为8%（18/228），ALL患者中为42%（88/210）；CT基因型的频率分别为39%（89/228）和29.5%（62/210）；TT基因型的频率分别为53%（121/228）和28.5%（60/210）。优势比为8.4（95%CI，4.7 - 15.5；P < 0.001）。这些数据表明，在墨西哥人群样本中，CYP1A1*2A基因型对成人ALL的易感性有显著影响。