Mikulecký Miroslav, Strestík Jaroslav
Department of Biometry and Statistics, Neuroendocrinology Letters, Stockholm, Sweden.
Isr Med Assoc J. 2007 Dec;9(12):835-8.
In the course of occurrence of cerebral infarction, cerebral hemorrhage and subarachnoidal hemorrhage episodes, periodicities resembling those found in the solar and geomagnetic activity were observed by Kovác and Mikulecký in 2005.
To investigate putative relationships between two indices of solar activity and one index of geomagnetic activity on one side and the occurrence of cerebral infarction on the other.
In addition to the 192 monthly cases out of 6100 new cases of cerebral infarction that occurred between January 1989 and December 2004, monthly averages for Wolf numbers, solar flares index and Ap index were included in the analysis. The cross-correlation between each cosmo-geophysical variable on the one hand and the number of new cases of the disease on the other was computed. The quadratic regression with the chosen time delay was also studied using, separately, the Wolf numbers, solar flares and Ap index as the explanatory variable and the number of cases of cerebral infarction as the responding variable.
Significantly negative correlation coefficients between the monthly means of the Wolf numbers, of solar flares and of Ap index on the one hand and monthly numbers of new cases of the disease on the other were found for the delays between -6 and +17 months. The cross-regression results for the delay of +5 months (infarction delayed after each cosmo-geophysical variable by 5 months) displayed a linear decrease except for the Wolf numbers where the parabolic decrease of cases was significant.
An increased intensity of the studied cosmo-geophysical parameters appears to be significantly connected with decreased occurrence of cerebral infarctions, and vice versa. This effect seems to last up to 17 months. The results are supported by a few similar findings in the literature. Putative cosmo-biomedical connections warrant further study to verify them in larger samples and longer time scales. If confirmed, their mechanisms should be elucidated.
2005年,科瓦奇和米库莱茨基观察到,在脑梗死、脑出血和蛛网膜下腔出血发作过程中,存在与太阳和地磁活动中发现的周期相似的周期性。
研究一方面太阳活动的两个指标和地磁活动的一个指标与另一方面脑梗死的发生之间的假定关系。
除了1989年1月至2004年12月期间6100例新发脑梗死病例中的192例月度病例外,分析还纳入了沃尔夫数、太阳耀斑指数和Ap指数的月度平均值。计算一方面每个宇宙地球物理变量与另一方面疾病新发病例数之间的交叉相关性。还分别以沃尔夫数、太阳耀斑和Ap指数作为解释变量,以脑梗死病例数作为响应变量,研究了具有选定时间延迟的二次回归。
在-6至+17个月的延迟时间内,发现沃尔夫数、太阳耀斑和Ap指数的月度平均值与疾病新发病例数之间存在显著的负相关系数。对于+5个月的延迟(梗死在每个宇宙地球物理变量之后延迟5个月)的交叉回归结果显示呈线性下降,但沃尔夫数的情况除外,病例数呈抛物线下降显著。
所研究的宇宙地球物理参数强度增加似乎与脑梗死发生率降低显著相关,反之亦然。这种效应似乎持续长达17个月。文献中的一些类似发现支持了这些结果。假定的宇宙生物医学联系值得进一步研究,以在更大样本和更长时间尺度上进行验证。如果得到证实,应阐明其机制。