金黄色葡萄球菌对利奈唑胺的耐药性：基因剂量效应、稳定性、适应性代价及交叉耐药性
Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.
作者信息
Besier Silke, Ludwig Albrecht, Zander Johannes, Brade Volker, Wichelhaus Thomas A
机构信息
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.
出版信息
Antimicrob Agents Chemother. 2008 Apr;52(4):1570-2. doi: 10.1128/AAC.01098-07. Epub 2008 Jan 22.
Abstract
Linezolid resistance in Staphylococcus aureus is typically associated with mutations in the 23S rRNA gene. Here we show that the accumulation of a single point mutation, G2576T, in the different copies of this gene causes stepwise increases in resistance, impairment of the biological fitness, and cross-resistance to quinupristin-dalfopristin and chloramphenicol.
摘要
金黄色葡萄球菌对利奈唑胺的耐药性通常与23S rRNA基因的突变有关。我们在此表明，该基因不同拷贝中单个点突变G2576T的积累会导致耐药性逐步增加、生物学适应性受损以及对奎奴普丁-达福普汀和氯霉素的交叉耐药。
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